We are engaged in multiple projects aimed at increasing the number and diversity genome sequences from enterobacteria.  These include plant pathogenic enterobacteria, which remain underrepresented among complete genomes available, as well as neglected genera isolated from a wide variety of sources.

We have built several tools to assist with annotation and comparative analysis of genome data.  These include Mauve, a widely used multiple genome aligner, and the ASAP database.  The Software section of this web site includes additional information about using and downloading these tools.  To logon to our installation of ASAP to browse and retrieve genome data use this link:

Enter ASAP now!

We use genome sequences and tools built here and elsewhere to try to understand the evolutionary history of genes, genomes and organisms.  Our interests include characterizing the relationship between major lineages of enterobacteria (link to Tree of Life website), exploring the role gene family expansion in adaptation to different environments, determining the impact of regulatory evolution in divergence of enterobacteria, and examining how the system-scale metabolic network evolves.